2004 Fiscal Year Final Research Report Summary
Differences in mechanism of regulatory system on energy metabolism between regenerating liver and hepatocellular carcinoma
| Project/Area Number |
15591453
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Aichi Medical University School of Medicine |
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Principal Investigator |
KOTAKE Katsuhiro Aichi Medical University, Department of Surgery, instructor, 医学部, 講師 (50351101)
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| Co-Investigator(Kenkyū-buntansha) |
KUROKAWA Tsuyoshi Aichi Medical University, School of Medicine, Assistent Professor, 医学部, 助教授 (50291406)
NONAMI Toshiaki Aichi Medical University, School of Medicine, Professor, 医学部, 教授 (80189422)
SHIMOMURA Yoshiharu Nagoya Institute of Technology, Professor, 工学部, 教授 (30162738)
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| Project Period (FY) |
2003 – 2004
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| Keywords | PPAR-α / CPT-1 / Hepatocellular carcinoma / Liver regeneration / Cirrhosis / Cyclin D1 / Mitochondria |
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| Research Abstract |
To evaluate the differences in mechanism of regulatory system on energy metabolism between regenerating liver and hepatooellular. Carcinoma, mRNAs for GAPDH and PPAR-α, CPT-1, Cyclin D1 were measured in hepatooellular carainama and cirrhotic human liver, rat remnant liver after 70% liver resection.
The levels of expression of mRNAs for GAPDH and PPAR-α, CPT-1, Cyclin D1 in hepatomllular carcinoma were significantly (p<0.01) increased by hepatooellular ca ranoma compared with those in carbolic liven
The levels of expression of mRNAs for GAPDH and Cyclin D1 in rat remnant liver one day after 70 % liver renedton were significantly (pm.05) higher than that one day afberr sham operation.
The levels of expression of mRNAs for GAPDH and Cyclin D1 in rat remnant liver three days after 70 % liver resection were significantly (p<0.01) higher than that three days after sham operation.
The levels of expression of mRNAs for PPAR-α and CPT-1 in rat remnant liver after 70 % liver resection were almost same as that after sham operation.
These results suggest that hepatocellular carcinoma may be associated with increase in metabolism of fatty acid in mitochondria, and that glucose may play more important role in liver regeneration after hepatectomy than fatty acid.
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