2004 Fiscal Year Final Research Report Summary
Research for Intrinsic Regulation against Cerebral Vasospasm and Ischemia after Aneurysmal Subarachnoid Hemorrhage
| Project/Area Number |
15591518
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Mie University |
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Principal Investigator |
SUZUKI Hidenori Mie University, Faculty of Medicine, Research Associate, 医学部, 助手 (90345976)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUSHIMA Satoshi Mie University, Faculty of Medicine, Assistant Professor, 医学部, 講師 (50252367)
TAKI Waro Mie University, Faculty of Medicine, Professor, 医学部, 教授 (70144368)
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| Project Period (FY) |
2003 – 2004
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| Keywords | Bilirubin / Cerebral vasospasm / Ferritin / Heme oxygenase / Iron / Subarachnoid hemorrhage |
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| Research Abstract |
We clarified the potential role of an inducible heme-metabolizing enzyme, heme oxygenase(HO)-1, and an inducible iron-detoxifying protein, ferritin, in cerebral vasospasm after aneurysmal subarachnoid hemorrhage(SAH). The authors measured the levels of bilirubin and iron, which are by-products of HO-1, and the ferritin levels in the cerebrospinal fluid after SAH, and determined the relation between these by-products of HO-1 or ferritin and vasospasm. The levels of ferritin, bilirubin and iron were all significantly elevated after SAH. The levels of ferritin and bilirubin were significantly higher in the group with no vasospasm than in the group with, asymptomatic and symptomatic vasospasm on Days 5 through 7 (P<0.05,respectively) and on Days 11 through 14 (P<0.025 in bilirubin) post-SAH. However, no significant difference was observed in the iron levels between these groups. In summary, this study showed that higher levels of bilirubin and ferritin in the cerebrospinal fluid after SAH were associated with no vasospasm. These findings support the concept that the induction of HO-1 and ferritin may be an intrinsic regulatory mechanism that acts against cerebral vasospasm.
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Research Products
(6 results)
