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2005 Fiscal Year Final Research Report Summary

Elucidation of genetic-environmental interaction and prevention for gestosis

Research Project

Project/Area Number 15591723
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionHOKKAIDO UNIVERSITY

Principal Investigator

KOBASHI Gen  Hokkaido University, Graduate school of Medicine, Assistant Prof., 大学院・医学研究科, 講師 (60270782)

Co-Investigator(Kenkyū-buntansha) MINAKAMI Hisanori  Hokkaido University, Graduate school of Medicine, Prof., 大学院・医学研究科, 教授 (40102256)
HATA Akira  Chiba University, Graduate school of Medicine, Prof., 大学院・医学研究科, 教授 (00244541)
Project Period (FY) 2003 – 2005
Keywordsgestosis / genotyping / stress / epidemiology / interview
Research Abstract

1.To clarify the interactions among the candidate gene polymorphisms for the occurrence of pregnancy-induced hypertension (PIH), we carried out genotyping of the genes associated with blood coagulation, such as C677T of methylenetetrahydrofolate reductase gene, Leiden mutation of factor V gene, G20210A of prothrombin gene and 4G/5G of plasminogen actibator inhibitor gene (PAI-I). The results showed that frequencies of 4G/4G of PAI-I ware 41% in PIH cases and 39% in controls, and no significant difference was found between them. However, frequencies of homozygote of T235 of angiotensinogen gene (AGT), which is reported risk factor for PIH, were significantly higher in PIH cases (78%, n=56) than controls (56%, n=121) in the subgroup possessing 4G/4G of PAI-I (p=0.008), while no significant difference was found between PIH cases (71%, n=82) than controls (60%, n=202) in the subgroup possessing 5G/5G or 4G/5G of PAI-I. Frequencies of heterozygote of Glu298Asp or homozygote of Asp298 of the endotherial nitric oxide synthase gene (NOS3), which is also reported risk factor for PIH, were 18% in PIH cases (n=51) and 10% in controls (n=114) in the subgroup possessing 4G/4G, and 30% in PIH cases (n=74) and 15% in controls (n=190) in the subgroup possessing 5G/5G or 4G/5G of PAI-I. Significant difference was found only in the latter subgroup (p<0.008).
2.In order to develop a stress checklist for pregnant women to use examinations and interventions, we performed personal interview and focus group interview in obstetrical department. Emesis, body change by pregnancy, health control methods during pregnancy, economical burden, relationship to parents, child care in the near future, etc. were found to be the stress factors of the pregnant women.

  • Research Products

    (10 results)

All 2006 2005

All Journal Article (9 results) Book (1 results)

  • [Journal Article] Genetic and Environmental Factors Associated with the Development of Hypertension in Pregnancy.2006

    • Author(s)
      Kobashi G.
    • Journal Title

      J Epidemiol 16

      Pages: 1-8

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Common variant (C677T) of methylenetetrahydrofolate reductase gene and Leiden mutation of factor V are not associated with recurrent spontaneous abortion of unexplained etiology in Japanese.2005

    • Author(s)
      Kobashi G, Kato EH, et al.
    • Journal Title

      Seminor Thromb Hemostat 31

      Pages: 266-271

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] The Egogram is a Potent, Independent Risk Factor for Hypertension in Pregnancy in Japanese Women.2005

    • Author(s)
      Kobashi G, Ohta K, et al.
    • Journal Title

      Seminor Thromb Hemostat 31

      Pages: 302-306

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Insertion/deletion polymorphism of angiotensin-converting enzyme gene and preeclampsia in Japanese.2005

    • Author(s)
      Kobashi G, Hata A, et al.
    • Journal Title

      Seminor Thromb Hemostat 31

      Pages: 346-350

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 妊娠高血圧症候群と血液凝固関連遺伝子多型2005

    • Author(s)
      小橋 元, 太田薫里, 他
    • Journal Title

      日本妊娠高血圧学会雑誌 13

      Pages: 64-67

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Common variant (C677T) of methylenetetrahydrofolate reducase gene and Leiden mutation of factor V are not associated with recurrent spontaneous abortion of unexplained etiology in Japanese.2005

    • Author(s)
      Kobashi G, Kato EH, et al.
    • Journal Title

      Seminor Thromb Hemostat 31

      Pages: 266-271

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] The Egogram is a Potent, Independent Risk Factor for Hypertension in Pregnancy in Japanese Women.2005

    • Author(s)
      Kobashi G, Ohta K, et al.
    • Journal Title

      Seminor Thromb Hemostat. 31

      Pages: 302-306

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Genetic variants of thrombosis and pregnancy-induced hypertension.2005

    • Author(s)
      Kobashi G, Ohta K, et al.
    • Journal Title

      JJSSHP 13

      Pages: 64-67

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Chapter IV Does Smoking Really Prevent Hypertension in Pregnancy? A Case-Control Study of Pregnant Women in Japan.2005

    • Author(s)
      Kobashi G.
    • Journal Title

      Trends in Smoking and Health Research (ed.by JH Owing.)

      Pages: 69-77

    • Description
      「研究成果報告書概要(欧文)」より
  • [Book] Trends in Smoking and Health Research (ed. by JH Owing.)2005

    • Author(s)
      Kobashi G.
    • Total Pages
      69-77
    • Publisher
      NOVA editors
    • Description
      「研究成果報告書概要(和文)」より

URL: 

Published: 2007-12-13  

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