2004 Fiscal Year Final Research Report Summary
POLYMORPHISMS OF IMMUNE-RELATED GENES ASSOCIATED WITH PATHOGENESIS OF ENDOMETRIOSIS
| Project/Area Number |
15591772
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | KYOTO PREFECTURAL UNIVERSITY OF MEDICINE |
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Principal Investigator |
KITAWAKI Jo Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Associate Professor, 医学研究科, 助教授 (00204925)
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| Project Period (FY) |
2003 – 2004
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| Keywords | ENDOMETRIOSIS / POLYMORPHISMS / CYTOKINES / TNF-α / INTERFERON-γ |
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| Research Abstract |
Endometriosis is defined by the presence of endometrium-like lesions outside the uterine cavity. Although the exact etiology and pathogenesis are unclear, genetic, endocrine, immune, and environment factors have been implicated in the disease. Familial and twin studies have indicated 5-8% increase in risk for first-degree relatives, suggesting that endometriosis is a genetic disorder with polygenic or multifactorial inheritance. Studies have implied a role for genetic factors in the association between the development of endometriosis and genetic polymorphisms.
Defects in the ability of cytotoxic T cells and natural killer (NK) cells to recognize and lyse ectopic endometrial cells are considered crucial for disease pathogenesis. NK cells recognize specifically the HLA class I molecules that inhibit the killing functions of these T cells. In the present study, we found that the HLA-A24-B^*0702-Cw^*0702-DRB1^*0101 haplotype and polymorphisms in the TNF-α gene promoter and interferon-γ gene are possible genetic susceptibility factors. Interleukin-10 gene promoter polymorphism is associated with production of anti-carbonic anhydrase II autoantibodies in patients with endometriosis.
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Research Products
(7 results)
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[Journal Article] Genetic contribution of tumor necrosis factor (TNF)-α gene promoter (-1031, -863 and -857) and TNF receptor 2 gene polymorphisms in endometriosis susceptibility2004
Author(s)
Teramoto M, Kitawaki J, Koshiba H, Kitaoka Y, Obayashi H, Hasegawa G, Nakamura N, Yoshikawa T, Matsushita M, Maruya E, Saji H, Ohta M, Honjo H
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Journal Title
American Journal of Reproductive Immunology 51
Pages: 352-357
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Genetic contribution of tumor necrosis factor (TNF) -α gene promoter (-1031, -863 and -857) and TNF receptor 2 gene polymorphisms in endometriosis susceptibility2004
Author(s)
Teramoto M, Kitawaki J, Koshiba H, Kitaoka Y, Obayashi H, Hasegawa G, Nakamura N, Yoshikawa T, Matsushita M, Maruya E, Saji H, Ohta M, Honjo H
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Journal Title
American Journal of Reproductive Immunology 51
Pages: 352-357
Description
「研究成果報告書概要(欧文)」より
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