2004 Fiscal Year Final Research Report Summary
Corticosteroid and catecholamine in central serous chorioretinopathy
| Project/Area Number |
15591842
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
IIDA Tomohiro Fukushima Medical University, Professor, 医学部, 教授 (50241881)
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| Co-Investigator(Kenkyū-buntansha) |
SAITO Masaaki Fukushima Medical University, Assistant, 医学部, 助手 (90363754)
MURAKAMI Masami Gunma University, Professor, 医学部, 教授 (30241871)
SATO Taku Gunma University, Assistant, 医学部, 助手 (70323350)
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| Project Period (FY) |
2003 – 2004
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| Keywords | central serous chorioretinopathy / endogenous corticosteroid / cortisol / s-IgA / fibrinous exudation |
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| Research Abstract |
Endogenous cortisol level and s-IgA level in sputum were determined in 31 patients with central serous chorioretinopathy and compared with 10 controls. There is no statistically significance in the mean values of the 13 pm cortisol (0.46+/-0.39) and s-IgA (196.4+/-158.3). The mean values of cortisol and s-IgA had no difference between acute phase of the disease and resolved phase.
Using optical coherence tomography (OCT), we also examined 13 consecutive eyes with central serous chorioretinopathy associated with ring-shaped fibrinous exudates. In the area of the grayish-white exudates, OCT showed moderately or highly reflective masses bridging the neurosensory retina and retinal pigment epithelium. Because the area of the pellucid core of the ring-shaped exudates showed an optically clear space beneath the neurosensory retina, the subretinal reflective masses were separated on cross-sectional images in all 13 eyes. The pellucid core of the exudates may be the route of the exudative fluid from the choroids into the subretinal space. A surrounding grayish white lesion seems to be fibrinous exudates that has accumulated in the subretinal space.
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