2004 Fiscal Year Final Research Report Summary
The elucidation of the mechanism of anterior capsule contraction and posterior capsule opacification after cataract surgery in patients with diabetes mellitus
| Project/Area Number |
15591847
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KATO Satoshi The University of Tokyo, Faculty of Medicine, Lecturer, 医学部附属病院, 講師 (20214372)
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| Co-Investigator(Kenkyū-buntansha) |
FUKUSHIMA Harumi The University of Tokyo, Faculty of Medicine, Assistant, 医学部附属病院, 助手 (10297517)
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| Project Period (FY) |
2003 – 2004
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| Keywords | Diabetes mellitus / Cytokine / after cataract / anterior capsule contraction / inflammation after surgery |
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| Research Abstract |
One-year prospective study indicated that the contraction of anterior capsule opening does not parallel with the development of posterior capsule opacity in patients with diabetes mellitus.
Lens epithelial cells (LECs) after cataract surgery had low IL-1 and TGF-β activities and increased during the proliferation and extension of epithelial cells in culture, in particular diabetic eyes.
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