2004 Fiscal Year Final Research Report Summary

The elucidation of the mechanism of anterior capsule contraction and posterior capsule opacification after cataract surgery in patients with diabetes mellitus

Research Project

Project/Area Number	15591847
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Ophthalmology
Research Institution	The University of Tokyo
Principal Investigator	KATO Satoshi The University of Tokyo, Faculty of Medicine, Lecturer, 医学部附属病院, 講師 (20214372)
Co-Investigator(Kenkyū-buntansha)	FUKUSHIMA Harumi The University of Tokyo, Faculty of Medicine, Assistant, 医学部附属病院, 助手 (10297517)
Project Period (FY)	2003 – 2004
Keywords	Diabetes mellitus / Cytokine / after cataract / anterior capsule contraction / inflammation after surgery
Research Abstract	One-year prospective study indicated that the contraction of anterior capsule opening does not parallel with the development of posterior capsule opacity in patients with diabetes mellitus. Lens epithelial cells (LECs) after cataract surgery had low IL-1 and TGF-β activities and increased during the proliferation and extension of epithelial cells in culture, in particular diabetic eyes.

(2 results)