2004 Fiscal Year Final Research Report Summary
Neuroprotective effects of hyperthermic preconditioning on regional brain ischemia
| Project/Area Number |
15591918
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Ehime University |
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Principal Investigator |
SHIRAKAWA Yoichi Ehime University, School of Medicine, Professor, 医学部, 教授 (90134600)
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| Co-Investigator(Kenkyū-buntansha) |
AIBIKI Mayuki Ehime University, School of Medicine, Associate Professor, 医学部, 助教授 (70148162)
HATA Ryuji Ehime University, School of Medicine, Associate Professor, 医学部, 助教授 (90258153)
DESAKI Junzou Ehime University, School of Medicine, lecturer, 医学部, 講師 (00036451)
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| Project Period (FY) |
2003 – 2004
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| Keywords | brain ischemia / preconditioning / ischemic tolerance / hyperthermia / adenosine receptor / Stat 3 |
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| Research Abstract |
In the rat-middle cerebral artery occlusion (MCAO) model, hyperthermic preconditioning given 18-24 hours before ischemic insults exhibited neuroprotective effects, which were attenuated by the pre-administration of selective adenosine Al receptor antagonist, 8-cyclopentyl-1,3-dipropylxanthine (DPCPX). We also examined the potential roles of Jak-Stat signaling pathway in ischemic insults. Stat3 of wild-type(wt), which was introduced into the cultured glia cells using an adenovirus vector, facilitated the cell death of neuron co-cultured with wt-Stat3-experessed glia. In rats which were given wt-Stat3-virus vector with stereotactic brain operation, volume of cerebral infarction increased after MCAO.
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