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2005 Fiscal Year Final Research Report Summary

Research of apoptosis induction by LPS and heat stress for pulp regeneration therapy

Research Project

Project/Area Number 15592025
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Conservative dentistry
Research InstitutionKyushu Dental College

Principal Investigator

KITAMURA Chiaki  Kyushu Dental College, School of Dentistry, Associate Professor, 歯学部, 助教授 (50265005)

Co-Investigator(Kenkyū-buntansha) NISHIHARA Tatsuji  Kyushu Dental College, School of Dentistry, Professor, 歯学部, 教授 (80192251)
TERASHITA Masamichi  Kyushu Dental College, School of Dentistry, Professor, 歯学部, 教授 (00118085)
Project Period (FY) 2003 – 2005
Keywordsdental pulp cells / odonotblast / apoptosis / regeneration therapy
Research Abstract

Recently, we demonstrated the in vivo relationship between pulp apoptosis induced by heat stress and pulp cell proliferation and differentiation for pulp regeneration during pulp wound healing (J. Dent. Res., 2001 ; J. Dent. Res., 2003 ; Oper. Dent., 2003 ; J. Endod. 2003). We also demonstrated that pulp cells exposed to heat stress show apoptosis and the thermo-tolerance, and that the survived pulp cells after heat stress phagocytose apoptotic pulp cells (J. Cell Biochem, 2005). Further, we examined the effects of sequential exposure of pulp cells to LPS and heat stress, and found that LPS has the unique effects on pulp cells through the modification and activation of HSF1, HSP27, Akt, and NF-κB/IκBα during sequential exposure to LPS and heat stress. Also, we examined the effects of hypoxia on pulp cell apoptosis and cell cycle arrest, and found that the cell cycle arrest and apoptosis was induced on pulp cells by hypoxia through the regulation of p21, cyclin D2,Rb, andp53.

  • Research Products

    (33 results)

All 2006 2005 2004 2003

All Journal Article (25 results) Book (8 results)

  • [Journal Article] Effects of sequential exposure to lipopolysaccharide and heat stress on dental pulp cells.2006

    • Author(s)
      Chiaki Kitamura
    • Journal Title

      Journal of Cellular Biochemistry (in press)

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Reoxygenation improves hypoxia induced pulp cell arrest.2006

    • Author(s)
      Yoshiko Ueno
    • Journal Title

      Journal of Dental Research (in press)

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Effects of sequential exposure to lipopolysaccharide and heat stress on dental pulp cells.2006

    • Author(s)
      Chiaki Kitamura
    • Journal Title

      Journal of Cellular Biochemistry

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Reoxygenation improves hypoxia induced pulp cell arrest.2006

    • Author(s)
      Yoshiko Ueno
    • Journal Title

      Journal of Dental Research

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Thermotolerance of pulp cells and phagocytosis of apoptotic pulp cells by surviving pulp cells following heat stress.2005

    • Author(s)
      Chiaki Kitamura
    • Journal Title

      Journal of Cellular Biochemistry 94・4

      Pages: 826-834

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] In vitro differentiation of dental epithelial progenitor cells through epithelial-mesenchymal interactions.2005

    • Author(s)
      Takahiko Morotomi
    • Journal Title

      Archives of Oral Biology 50・8

      Pages: 695-705

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Thermotolerance of pulp cells and phagocytosis of apoptotic pulp cells by surviving pulp cells following heat stress.2005

    • Author(s)
      Chiaki Kitamura
    • Journal Title

      Journal of Cellular Biochemistry 94-4

      Pages: 826-834

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] In vitro differentiation of dental epithelial progenitor cells through epithelial-mesenchymal interactions.2005

    • Author(s)
      Takahiko Morotomi
    • Journal Title

      Archives of Oral Biology 50-8

      Pages: 695-705

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Efficacy of ozone on survival and permeability of oral microorganisms.2004

    • Author(s)
      Masato Nagayoshi
    • Journal Title

      Oral Microbiology and Immunology 19・4

      Pages: 240-246

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Antimicrobial effect of ozonated water on bacteria invading to dentinal tubules.2004

    • Author(s)
      Masato Nagayoshi
    • Journal Title

      Journal of Endodontics 30・11

      Pages: 778-781

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Apoptosis in pulp wound healing.2004

    • Author(s)
      Masamichi Terashita
    • Journal Title

      Dentistry in Japan 40

      Pages: 43-47

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 歯髄創傷治癒・再生におけるアポトーシス.2004

    • Author(s)
      北村 知昭
    • Journal Title

      日本歯科保存学会雑誌 47・6

      Pages: 764-766

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Efficacy of ozone on survival and permeability of oral microorganisms.2004

    • Author(s)
      Masato Nagayoshi
    • Journal Title

      Oral Microbiology and Immunology 19-4

      Pages: 240-

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Antimicrobial effect of ozonated water on bacteria invading to dentinal tubules.2004

    • Author(s)
      Masato Nagayoshi
    • Journal Title

      Journal of Endodontics 30-11

      Pages: 778-781

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Apoptosis in pulp wound healing and regeneration2004

    • Author(s)
      Chiaki Kitamura
    • Journal Title

      The Japanese Journal of Conservative Dentistry 47-6

      Pages: 764-766

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Effects of the cavity size on the apoptosis-induction during pulp wound healing.2003

    • Author(s)
      Chiaki Kitamura
    • Journal Title

      Operative Dentistry 28・1

      Pages: 75-79

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Differential induction of apoptosis by capping agents during pulp wound healing.2003

    • Author(s)
      Chiaki Kitamura
    • Journal Title

      Journal of Endodontics 29・1

      Pages: 41-43

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Transient co-localization of c-Jun N-terminal kinase and c-Jun with heat shock protein 70 in pulp cells during apoptosis.2003

    • Author(s)
      Chiaki Kitamura
    • Journal Title

      Journal of Dental Research 82・2

      Pages: 91-95

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] マウス歯胚における血管内皮増殖因子(VEGF)とVEGFレセプター2(VEGFR2/Flk-1)の局在2003

    • Author(s)
      尾川 幸雄
    • Journal Title

      日本歯科保存学会雑誌 46・1

      Pages: 37-45

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Free D-aspartic acid in rat salivary glands.2003

    • Author(s)
      Wataru Masuda
    • Journal Title

      Archives of Biochemistry and Biophysics 420・1

      Pages: 46-54

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Effects of the cavity size on the apoptosis-induction during pulp wound healing.2003

    • Author(s)
      Chiaki Kitamura
    • Journal Title

      Operative Dentistry 28-1

      Pages: 75-79

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Differential induction of apoptosis by capping agents during pulp wound healing.2003

    • Author(s)
      Chiaki Kitamura
    • Journal Title

      Journal of Endodontics 29-1

      Pages: 41-43

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Transient co-localization of c-Jun N-terminal kinase and c-Jun with heat shock protein 70 in pulp cells during apoptosis.2003

    • Author(s)
      Chiaki Kitamura
    • Journal Title

      Journal of Dental Research 82-2

      Pages: 91-95

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Localizations of vascular endothelial growth factor (VEGF) and VEGF receptor 2 (VEGF2/Flk-1) during mouse tooth development2003

    • Author(s)
      Yukio Ogawa
    • Journal Title

      The Japanese Journal of Conservative Dentistry 46-1

      Pages: 37-45

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Free D-aspartic acid in rat salivary glands.2003

    • Author(s)
      Wataru Masuda
    • Journal Title

      Archives of Biochemistry and Biophysics 450-1

      Pages: 46-54

    • Description
      「研究成果報告書概要(欧文)」より
  • [Book] 歯科臨床ハンドブック-臨床ヒント集ダイジェスト版-2005

    • Author(s)
      北村 知昭
    • Total Pages
      599
    • Publisher
      クイッテセンス出版株式会社
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] Clinical handbook for dentistry, digests of clinical hints.2005

    • Author(s)
      Chiaki Kitamura
    • Total Pages
      599
    • Publisher
      Quintessence Publishing Co, Ltd.,
    • Description
      「研究成果報告書概要(欧文)」より
  • [Book] The Quintessence YEARBOOK 2003 現代の治療指針 全治療分野とカリオロジー2004

    • Author(s)
      北村 知昭
    • Total Pages
      401
    • Publisher
      クイッテセンス出版株式会社
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] 歯科医療現場における感染制御のためのCDCガイドライン.2004

    • Author(s)
      北村 知昭
    • Total Pages
      182
    • Publisher
      メディカ出版
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] カラーアトラスハンドブック保存修復臨床ヒント集.2004

    • Author(s)
      北村 知昭
    • Total Pages
      217
    • Publisher
      クイッテセンス出版株式会社
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] The Quintessence Year Book 2003 Current guidance of dental treatment. All categories and cardiology.2004

    • Author(s)
      Chiaki Kitamura
    • Total Pages
      401
    • Publisher
      Quintessence Publishing Co, Ltd.,
    • Description
      「研究成果報告書概要(欧文)」より
  • [Book] CDC guideline for the infection control in dentistry.2004

    • Author(s)
      Chiaki Kitamura
    • Total Pages
      182
    • Publisher
      Medicus shuppan
    • Description
      「研究成果報告書概要(欧文)」より
  • [Book] Color atlas handbook, clinical hints for operative dentistry.2004

    • Author(s)
      Chiaki Kitamura
    • Total Pages
      217
    • Publisher
      Quintessence Publishing Co, Ltd.,
    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2008-05-27  

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