Research for effect of anti cancer drugs against primary site and lymph node metastatic site in human oral cancer

2004 Fiscal Year Final Research Report Summary

• Project/Area Number: 15592094
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: TOHOKU UNIVERSITY
• Principal Investigator: NITTA Yasutaka Tohoku University, Hospital, Research Associate, 病院, 助手 (80250794)
• Co-Investigator(Kenkyū-buntansha): TAKEBAYASHI Yuji Fukushima Medical University, School of Medicine, Lecturer, 医学部, 講師 (70321982)
• Project Period (FY): 2003 – 2004
• Keywords: Cancer Chemotherapy / Drag resistance / Membrane Transporter / Oral Cancer

Research Abstract

First, the expression levels of the target molecules for cancer chemotherapy such as drug transporters (ATP7B, MRP,2), DNA repair molecules (XPG, XPF) and the targets for FU such as TP, DPD, TS were examined by RT-PCR and immunohistochemical analysis in oral cancer. The expression levels of TP and TS were different between primary and lymph node metastatic lesions among the examined molecules. Next, using the transfectants of TS or TP, the enhancement of the expression levels of these molecules were examined in murine models. Unfortunately, the enhancement of these molecules were not obtained.

Research Products

• [Journal Article] Expression of copper-transporting P-type adenosine triphosphatase (ATP7B) in human hepatocellular carcinoma. (2004)
  • Author(s): Sugeno H, Takebayashi Y, Nitta Y他
  • Journal Title: Anticancer Research 24 Pages: 1045-1048
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] The role of thymidine phosphorylase, an angiogenic enzyme, in tumor progression. (2004)
  • Author(s): Takebayashi Y.他
  • Journal Title: Cancer Science 95 Pages: 851-857
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Prognostic value of the Cu-transporting ATPase in ovarian carcinoma patients receiving cisplatin-based chemotherapy. (2004)
  • Author(s): Takebayashi Y.他
  • Journal Title: Clinical Cancer Research 10 Pages: 2804-2811
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Expression of copper-transporting P-type adenosine triphosphatase (ATP7B) in human hepatocellular carcinoma. (2004)
  • Author(s): Sugeno H, Takebayashi Y, Higashimoto M, Ogura Y, Shibukawa G, Kanzaki A, Terada K, Sugiyama T, Watanabe K, Katoh R, Nitta Y, Fukushima T, Koyama Y, Inoue N, Sekikawa K, Ogawa K, Sato Y, Takenoshita S.
  • Journal Title: Anticancer Research Mar-Apr;24(2C) Pages: 1045-1048
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The role of thymidine phosphorylase, an angiogenic enzyme, in tumor progression. (2004)
  • Author(s): Akiyama S, Furukawa T, Sumizawa T, Takebayashi Y, Nakajima Y, Shimaoka S, Haraguchi M.
  • Journal Title: Cancer Science Nov;95(11) Pages: 851-857
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Prognostic value of the Cu-transporting ATPase in ovarian carcinoma patients receiving cisplatin-based chemotherapy. (2004)
  • Author(s): Nakayama K, Kanzaki A, Terada K, Mutoh M, Ogawa K, Sugiyama T, Takenoshita S, Itoh K, Yaegashi N, Miyazaki K, Neamati N, Takebayashi Y.
  • Journal Title: Clinical Cancer Research Apr 15;10(8) Pages: 2804-2811
  • Description: 「研究成果報告書概要(欧文)」より