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2015 Fiscal Year Annual Research Report

マイクロ工学によるがん微小環境モデルの構築

Research Project

Project/Area Number 15F15767
Research InstitutionThe University of Tokyo

Principal Investigator

松永 行子 (津田行子)  東京大学, 生産技術研究所, 講師 (00533663)

Co-Investigator(Kenkyū-buntansha) PAUTY JORIS  東京大学, 生産技術研究所, 外国人特別研究員
Project Period (FY) 2015-11-09 – 2018-03-31
Keywordsin vitro model / tissue engineering / vascular biology / cancer
Outline of Annual Research Achievements

During the Fiscal Year 2015, we have achieved the implantation of the technique of cancer spheroid formation within the laboratory. This was the first milestone in the realization of our final goal which is the development of a 3D-in vitro tumor model on-a-chip. To reach that goal, another key step is to develop a new “chip” that allows the combination of a blood vessel model - technology available in the lab, with a cancer spheroid. We designed 2 prototypes that are currently under investigations. These devices raised some technical issues and solving them may requires to design other prototypes. From another hand, we have started to work on a perfusion system that use a peristaltic pump.

Current Status of Research Progress
Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

The research has been going well as we expected. However, we had to carry over the budget (0.3 million yen) to Fiscal Year 2016 because the date of workshop in France had been extended to Fiscal Year 2016. The carried budge was appropriately used for the expense of travel.

Strategy for Future Research Activity

In the coming fiscal year, we are planning to communicate about our progress at the international conference named TERMIS (Tissue Engineering International & Regenerative Medicine Society), as well as during the annual meetings with our french collaborators of SMMiL-E and LiMMS.

  • Research Products

    (6 results)

All 2016 2015 Other

All Int'l Joint Research (1 results) Presentation (3 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results) Remarks (2 results)

  • [Int'l Joint Research] CNRS/INSERM(France)

    • Country Name
      France
    • Counterpart Institution
      CNRS/INSERM
  • [Presentation] ボトムアップ組織工学による生体組織構造の構築2016

    • Author(s)
      松永行子
    • Organizer
      医用・生体工学研究会
    • Place of Presentation
      東京大学先端科学技術研究センター, 東京
    • Year and Date
      2016-03-22
    • Invited
  • [Presentation] マイクロ加工技術を利用した生体組織構造のデザイン:血管新生モデル2016

    • Author(s)
      松永行子
    • Organizer
      第4回次世代がん治療推進専門家養成プランシンポジウム
    • Place of Presentation
      東京医科歯科大学, 東京
    • Year and Date
      2016-01-23
    • Invited
  • [Presentation] Microvasculature Chip for Angiogenesis Study2015

    • Author(s)
      Y.T. Matsunaga, F. Soncin
    • Organizer
      Workshop on BioMEMS and Cancer
    • Place of Presentation
      IBL, Lille, France
    • Year and Date
      2015-12-17
    • Int'l Joint Research
  • [Remarks] LIMMS/CNRS-IIS (2820) 国際連携研究センター

    • URL

      https://www.iis.u-tokyo.ac.jp/ja/research/department_center/limms/

  • [Remarks] Matsunaga laboratory, IIS, UTokyo

    • URL

      http://www.matlab.iis.u-tokyo.ac.jp/index.html

URL: 

Published: 2018-01-16  

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