2016 Fiscal Year Annual Research Report
| Project/Area Number |
15F15767
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| Research Institution | The University of Tokyo |
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Principal Investigator |
松永 行子 (津田行子) 東京大学, 生産技術研究所, 講師 (00533663)
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| Co-Investigator(Kenkyū-buntansha) |
PAUTY JORIS 東京大学, 生産技術研究所, 外国人特別研究員
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| Project Period (FY) |
2015-11-09 – 2018-03-31
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| Keywords | cancer / blood cessel / barrier function / angiogenesis / tumor microenvironment / organ on a chip |
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| Outline of Annual Research Achievements |
During the Fiscal Year 2016, we optimized the fabrication of in vitro microvessels using a newly designed microchip. Microvessels of a better quality were therefore obtained and we could develop a permeability assay, which is useful to study the endothelial barrier function - a key role of blood vessel. This work has been published in Nanotheranostics (2017, doi:10.7150/ntno.18303). We have also been working on an angiogenesis assay. Both assays are required to study cancer microenvironment, because a tumor alters the barrier function and angiogenic property of blood vessels in order to facilitate its growth and metastasis. Recently, we have been doing preliminary works on coculture of cancer cells with our microvessel as well as working on overcoming technical challenges regarding coculture with cancer spheroids as an in vitro tumor model. In addition, Dr. Pauty's activity was highlighted in the article of "nature jobs" entitled with "Spotlight on Technology Universities in Japan". (NatureJobs (2016) doi:10.1038/nj0489)
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| Current Status of Research Progress |
Current Status of Research Progress
2: Research has progressed on the whole more than it was originally planned.
Reason
Things going smoothly as we expected.
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| Strategy for Future Research Activity |
In the coming fiscal year, we are planning to study the barrier function and angiogenesis of our microvessels when it is cocultured with cancer cells. It will provide information regarding how cancer cells modify their environment to better grow or do metastasis. We are also expecting to coculture microvessels with cancer spheroids in a newly design microchip. It will allow us to study angiogenesis directed toward a tumor.
Regarding scientific communication, we are expecting to submit our results regarding the angiogenesis assay to an international scientific journal in the beginning of the fiscal year. Later on, we will communicate about our progress during the annual meetings with our french collaborators of SMMiL-E and LiMMS.
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