Functions of BAF complex in DNA repair and cancer therapy

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H01737
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Risk sciences of radiation and chemicals
• Research Institution: Tohoku University
• Principal Investigator: YASUI Akira 東北大学, 加齢医学研究所, 加齢研フェロー (60191110)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: DNA修復 / ヌクレオゾームリモデリング / BAF複合体 / ARID1A / ARID1B / 細胞癌化 / 細胞老化 / 癌治療

Outline of Final Research Achievements

We found that BAF complex belonging to the SWI/SNF family for ATP-dependent chromatin remodeling (nucleosome remodeling) not only contributes to transcriptional regulation but also to DNA repair of various types of DNA damage and identified BAF factors involved in DNA repair. ARID1A and ARID1B, mutually exclusive variant factors for transcription in BAF complex, turned out to interact with KU protein and to contribute to DNA double-strand break repair. Thus, when cell ages, nucleosome remodeling, DNA repair and transcriptional regulation can build a negative feedback loop to promote tumorigenesis and accelerate cellular aging, as DNA repair defect creates mutation influencing NR and TR.

Free Research Field

DNA修復の機構の解明。ヌクレオゾームリモデリングの修復への影響、細胞癌化と老化と癌治療の開発