Mechanisms of inflammation control in functional phytochemicals: Counterplans against lifestyle-related diseases based on chronic inflammation

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H01767
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Eating habits
• Research Institution: Tokyo University of Agriculture
• Principal Investigator: UEHARA Mariko 東京農業大学, 応用生物科学部, 教授 (20211071)
• Co-Investigator(Kenkyū-buntansha): 高橋 信之 東京農業大学, 応用生物科学部, 准教授 (50370135) ; 井上 博文 東京農業大学, 応用生物科学部, 助教 (10639305)
• Co-Investigator(Renkei-kenkyūsha): KATSUMATA Shin-ichi 東京農業大学, 応用生物科学部, 准教授 (10424681)
• Research Collaborator: Felix Angelina DR. University of the Philippines Los Baños, Institute of Human Nutrition and Food, College of Human Ecology, Associate Professor ; IKUSHIRO Shin-ichi 富山県立大学, 工学研究科, 教授 ; MUROTA Kaeko 島根大学, 生物資源科学部, 教授 ; KATSUMATA Rie (TSUBOI Rie) 東京農業大学, 応用生物科学部, 助手
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: ファイトケミカル / ポリフェノール / 含硫化合物 / 炎症制御 / ロコモティブシンドローム / メタボリックシンドローム / 破骨細胞 / シグナル伝達

Outline of Final Research Achievements

In this study, we focused on the anti-inflammatory effects of functional phytochemicals, and aimed at simultaneous prevention of lifestyle-related diseases caused by chronic inflammation, especially locomotive/metabolic syndromes. First, we screened anti-inflammatory effects of phytochemicals by using osteoclasts (OC) in vitro, since OC is activated in inflammatory condition. Equol enantiomers, isoflavone metabolites, and suforaphane, a sulfur-containing compound, were found as effective compounds for anti-osteoclastogenesis. We determined the detailed mechanism in OC, and examined the anti-inflammatory effects of those phytochemicals in chronic inflammatory disease modeled animals. Regarding anti-metabolic syndrome, we used black/brown rice extracts, which involved anthocyanins and other ingredients as physiological active substances. The extracts inhibited hepatic fat accumulation via activation of PPAR-alpha in obese and type II diabetes model mouse with high fat diet intake.

Free Research Field

食品機能学