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2017 Fiscal Year Final Research Report

Innovation of multi-Drug delivery platform based on the ssPalm: Immune-engineering and cancer therapy

Research Project

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Project/Area Number 15H01806
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionChiba University (2016-2017)
Hokkaido University (2015)

Principal Investigator

Hidetaka Akita  千葉大学, 大学院薬学研究院, 教授 (80344472)

Project Period (FY) 2015-04-01 – 2018-03-31
Keywords癌免疫 / ナノ粒子 / 環境応答性材料 / ワクチン / DNA
Outline of Final Research Achievements

For the success of the cancer immune therapy, activation of antigen-specific cytotoxic T cell (CTL) is quite important. DNA vaccine is principally useful technology to induce this CTL activity. Meanwhile, the intra-tumor region is considered to be an immune-suppressive environment. Thus, for the effective function of the cancer vaccine, the normalization/ neutralization of the immune-suppressive machinery is essential in parallel.
Currently, we have developed a lipid nanoparticle composed of intracellular environment-responsive material (ss-cleavable and pH-activated lipid-like material: ssPalm) as a technology to overcome the biomembranes barrier, and spontaneous collapse. In this project, we developed a delivery system of Genes, and small compounds using ssPalm as a fundamental platform, and applied them for the immune-engineering for cancer therapy.

Free Research Field

薬剤学

URL: 

Published: 2019-03-29  

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