Synthesis and characterization of flexible smart hybrid with specific shape

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H02296
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Composite materials/Surface and interface engineering
• Research Institution: Nagoya University
• Principal Investigator: Yogo Toshinobu 名古屋大学, 未来材料・システム研究所, 名誉教授 (00135310)
• Co-Investigator(Renkei-kenkyūsha): SAKAMOTO Wataru 名古屋大学, 未来材料システム研究所, 准教授 (50273264) ; HAYASHI Koichiro 九州大学, 大学院歯学研究院, 准教授 (80580886)
• Research Collaborator: HAYASHI Hikaru ; YAMADA Shota
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: ハイブリッド材料 / 特異形状 / 赤血球状粒子 / 体内動態

Outline of Final Research Achievements

Red-blood-cell like micro particles (RBC-MPs) consisting of cellulose were successfully synthesized. RBC-MPs were intravenously administrated to mice, and their pharmacokinetics were investigated by fluorescence imaging. RBC-MPs avoided the accumulation in the lung and spleen, but accumulated specifically in the liver. Based on the pharmacokinetics of RBC-MPs, the drug to heal fibrosis was incorporated to RBC-MPs, and delivered specifically to the liver. The fibrous was successfully cured without any side effect. In addition, RBC-MPs dispersed with magnetic nanoparticles was molecularly imprinted with cortisol were found to trap cortisol selectively, and to be recoverd by magnet.

Free Research Field

複合材料