Exploring the mechanism of cardiac development and regeneration based on diverse cellular origins

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H02536
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: The University of Tokyo
• Principal Investigator: Kurihara Hiroki 東京大学, 大学院医学系研究科(医学部), 教授 (20221947)
• Co-Investigator(Kenkyū-buntansha): 富田 幸子 ヤマザキ学園大学, 動物看護学部, 教授 (40231451)
• Co-Investigator(Renkei-kenkyūsha): WADA Yoichiro 東京大学, アイソトープ総合センター, 教授 (10322033) ; KURIHARA Yukiko 東京大学, 大学院医学系研究科, 講師 (80345040) ; UCHIJIMA Yasunobu 東京大学, 大学院医学系研究科, 助手 (90272426)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 分子心臓学 / 発生・分化 / 循環器

Outline of Final Research Achievements

We identified the preotic neural crest and amniogenic somatopleural mesoderm as novel origins of cardiovascular components, found phenotypic diversity within each lineage by single-cell transcriptome analysis, and revealed signals that possibly regulate their differentiation and migration. In coronary artery development, we found the involvement of coordination between cells giving rise to the coronary ostia and forming lymphatic vessels. The signaling molecules mediating their interaction are also involved in post-ischemic cardiac injury, which indicates their potential as a novel therapeutic target in myocardial infarction.

Free Research Field

医歯薬学