2017 Fiscal Year Final Research Report
Analysis of regulation of chondrocyte differentiation by SIK3 and lipid metabolism
| Project/Area Number |
15H02561
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 軟骨細胞 / 分化 / SIK3 / コンディショナルノックアウトマウス |
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| Outline of Final Research Achievements |
Cartilage plays important roles in joint motion and bone growth. In this project, we created conditional knockout mice and found that SIK3 regulates properties of articular cartilage and can be a target molecule for osteoarthritis. We showed that a SIK3 inhibitor rescues the mice with the osteoarthritis model and can be a lead molecule for drug. In a separate experiment, we found a molecule that sustains chondrocytic properties of chondrocytes. This compound inhibited degradation of Sox9 which is important for maintenance of chondrocytic phenotype.
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| Free Research Field |
骨・軟骨代謝学
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