Investigation of the role myeloid-derived suppressor cells (MDSC) in the maternal-fetal tolerance and pregnancy-complicated female cancer progression.

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H02564
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Osaka University
• Principal Investigator: Kimura Tadashi 大阪大学, 医学系研究科, 教授 (90240845)
• Co-Investigator(Kenkyū-buntansha): 馬淵 誠士 大阪大学, 医学系研究科, 助教 (00452441) ; 遠藤 誠之 大阪大学, 医学系研究科, 講師 (30644794) ; 熊澤 惠一 大阪大学, 医学系研究科, 助教 (90444546)
• Research Collaborator: Matsumoto Yuri ; Takahashi Ryoko ; Sasano Tomoyuki ; Kuroda Hiromasa ; Kozasa Katsumi ; Yokoi Eriko ; Komura Naoko
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: MDSC / エストロゲン / 妊娠 / 子宮頸癌 / 流産

Outline of Final Research Achievements

We have investigated the impact of estradiol (E2) in the induction of MDSC as well as the roles of E2-induced MDSC in maternal-fetal tolerance or cervical cancer progression during pregnancy. We have found that E2 enhanced the proliferation of bone marrow (BM) cells, and stimulated the differentiation of BM cells into MDSC. We also found that increased E2 level during pregnancy is involved in the maternal-fetal tolerance as well as cervical cancer progression, which read to the enhanced progression of cervical/breast cancers during pregnancy. Finally we identified a novel agent PM01183, which exhibits strong inhibitory effects on MDSCs. We are conducting clinical researches to verify these preclinical findings in human.

Free Research Field

医歯薬学