Construction of analyses basis for understanding rare variants using protein structural information

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H02773
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Life / Health / Medical informatics
• Research Institution: Tohoku University
• Principal Investigator: Kinoshita Kengo 東北大学, 情報科学研究科, 教授 (60332293)
• Co-Investigator(Renkei-kenkyūsha): SHIRAI TSUYOSHI 長浜バイオ大学, バイオサイエンス学部, 教授 (00262890) ; OHTA MOTONORI 名古屋大学, 大学院情報科学研究科, 教授 (40290895)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 低頻度変異 / タンパク質立体構造 / ホモロジーモデリング / ヒトタンパク質

Outline of Final Research Achievements

We could construct the proposed systems as planned, which can map genetic variations onto protein structures, and the results are available through the web site called snvmap. For the purpose, we generated model structures of human proteins, if they are not available in PDB.
By using the mapping results, we performed statistical analyses and found some interesting rare variations related with the metabolism of oseltamivir, an anti-virus drug, which specific for east Asian populations.

Free Research Field

バイオインフォマティクス