2017 Fiscal Year Final Research Report
Analysis of the transcriptional regulatory mechanism of nuclear receptors via posttranslational modification of the nuclear receptors and localization of the interacting factors
| Project/Area Number |
15H02896
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
土井 健史 大阪大学, 薬学研究科, 教授 (00211409)
石本 憲司 大阪大学, 薬学研究科(研究院), 助教 (00572984)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 核内受容体 / 翻訳後修飾 / PPARα活性化剤 / 蛋白質 分解 / LPIN / SETDB1 |
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| Outline of Final Research Achievements |
Both PPAR and LXR are ligand-activated transcription factors that play pivotal roles in regulating lipid homeostasis. In the present study, we developed novel PPARα ligands that act in vivo to reduce plasma triglyceride levels. We also revealed that LPIN1, having dual functions in the regulation of lipid metabolism, is degraded by the E3 ubiquitin ligase BTRC. Furthermore, we investigated the subcellular localization and enzymatic activity regulation of the histone methyltransferase SETDB1. These findings will be useful for developing the drugs to treat metabolic diseases.
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| Free Research Field |
分子代謝学
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