Preventive effect of dietary flavonoids on nocturnal light exposure-related diseases

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H02899
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Eating habits
• Research Institution: University of Shizuoka
• Principal Investigator: SHIMOI Kayoko 静岡県立大学, 食品栄養科学部, 教授 (10162728)
• Co-Investigator(Kenkyū-buntansha): 保田 倫子 椙山女学園大学, 生活科学部, 講師 (00707036)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 光環境ストレス / 明暗シフト / 乳がん転移 / 血栓症 / 心疾患 / リンパ管 / フラボノイド / 予防

Outline of Final Research Achievements

Epidemiological studies indicated that disturbed circadian rhythm caused by night shift work is a　potential risk factor for breast cancer and cardiovascular diseases. In this study, we investigated influences of nocturnal light exposure on thrombosis factors in male C3H/He mice and those of light and dark cycle shift on atherosclerosis and breast cancer metastasis using female BALB/c.KOR/StmSLc-ApoEshl mice and BALB/c mice injected BJMC3879luc2 breast cancer cells, respectively. And chemopreventive effect of quercetin, a dietary flavonoid, was also studied. Nocturnal light exposure for 3 h affected expression of Pai-1, tPA and TF genes related to thrombogenesis in the heart. Circadian dysfunction did not affect development of atherosclerosis and primary tumor growth, however, increased the number of lymph node with metastasis. 0.1% quercetin diet suppressed expression of genes related to metastasis in the tumor. Effect of quercetin on lymphangiogenesis is under investigation.

Free Research Field

生体機能学、食品機能学