Unstained tumor detection in digestive organs based on auto fluorescence spectroscopy

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H03013
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: National Institute of Advanced Industrial Science and Technology
• Principal Investigator: Arimoto Hidenobu 国立研究開発法人産業技術総合研究所, エレクトロニクス・製造領域, 主任研究員 (50344198)
• Co-Investigator(Kenkyū-buntansha): 田中 信治 広島大学, 病院(医), 教授 (00260670) ; 香川 景一郎 静岡大学, 電子工学研究所, 准教授 (30335484)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 生体イメージング / 蛍光スペクトル解析 / 癌検出 / 蛍光寿命 / イメージセンサー

Outline of Final Research Achievements

We have studied the technique for unstained tumor detection imaging based on the autofluorescence spectra of coenzymes NADH and FAD. First, we measured the autofluorescence spectra of the coenzymes and calculated REDOX index which represents the metabolism in organs. The normalized REDOX index has been found to be highly correlated with the presence of the tumor. Next, we measured the REDOX index along the depth direction of the tumor organs. The results showed the possibility of estimating the presence of the tumor to the depth direction. Finally, we have measured fluorescence lifetime for more precise tumor detection. The lifetime was plotted using Feather plotting method. From there results, it was suggested that appropriate combination of these techniques will leads to high precision of the tumor detection technique.

Free Research Field

医用生体光学