2017 Fiscal Year Final Research Report
Development of transscleral multi-drug delivery device for retinal disease treatment
| Project/Area Number |
15H03015
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Biomedical engineering/Biomaterial science and engineering
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | 薬物送達 / 生体材料 / 眼科学 / 網膜 |
|---|
| Outline of Final Research Achievements |
Purpose is the evaluation of a transscleral multi-drug delivery device for clinical practice. We developed a flexible device that can fit on the curvature of the eyeball by using a silicon material and stainless wire. Pharmacokinetics in the eye was evaluated for 1 year using rabbits and monkeys. Safety in the retinal function 1 year after device implantation was confirmed. Pharmacological effects in transgenic retinal degeneration model rabbits was confirmed. Scar formation around the device did not affect the retinal function. Enhanced drug delivery by simultaneous cyclosporine A release was indicated. Devices for clinical use was stable for 24 months and safe biologically.
|
| Free Research Field |
網膜ドラッグデリバリーシステム
|
