Fabrication of highly active antigen nanocarriers by integration of immunity-inducing functions and their application to cancer immunotherapy

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H03024
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Osaka Prefecture University
• Principal Investigator: YUBA Eiji 大阪府立大学, 工学(系)研究科(研究院), 准教授 (80582296)
• Co-Investigator(Kenkyū-buntansha): 宇高 恵子 高知大学, 教育研究部医療学系基礎医学部門, 教授 (40263066)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: リポソーム / がん免疫療法 / pH応答性高分子 / アジュバント / 免疫抑制解除 / がん抗原ペプチド / がんワクチン / 細胞傷害性Tリンパ球

Outline of Final Research Achievements

In this study, we developed cancer antigen-loaded liposome-based nanocarrier systems integrated functional molecules for intracellular antigen delivery, activation of immune cells and cancel of immunosuppression. Integration of purposeful functional molecules for cancer immunotherapy to liposomes achieved the induction of antigen-specific immune responses and highly cancer therapeutic effect on tumor-bearing mice models. Therefore, these nanocarrier systems are promising as immunity-inducing systems for cancer immunotherapy.

Free Research Field

生体関連高分子、ドラッグデリバリーシステム、免疫誘導システム