Development of immunoceramics acting on immune system and their functions

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H03025
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Meiji University
• Principal Investigator: Aizawa Mamoru 明治大学, 理工学部, 専任教授 (10255713)
• Co-Investigator(Kenkyū-buntansha): 永井 重徳 東京医科歯科大学, 大学院医歯学総合研究科, 准教授 (50348801)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 免疫療法 / イムノセラミックス / ゾル-ゲル法 / 水酸アパタイト / ホウ素含有アパタイト / 免疫細胞 / T細胞 / フローサイトメーター

Outline of Final Research Achievements

Hydroxyapatite (HAp) are one of the important key materials in the field of biomaterials. Recently, immunotherapy without side effects has been expected as a novel medical treatment for a cancer. In order to create the novel cell-culture substrates for enhancing the activity of immune cells, we have developed the two types “immunoceramics” on the bases of i) boron-containing apatite (BAp) with BO2 groups and ii) HAp ceramics surface-modified with inositol phosphate (IP6) (hereafter, IP6-HAp ceramics). Splenocytes derived from the spleen of mouse were seeded on these immnoceramics to examine the activation ability using a flow cytometry. The results showed that the populations of splenocytes with the immunoceramics were higher than that of the splenocytes with the HAp ceramics as a control. The present two immunoceramics may be expected as key materials for next-generation immunotherapy for a cancer.

Free Research Field

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