Design of Spatiotemporally Controllable Smart Medical Systems Using Dynamic Cross-linked Gels

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H03026
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Kansai University
• Principal Investigator: Miyata Takashi 関西大学, 化学生命工学部, 教授 (50239414)
• Co-Investigator(Kenkyū-buntansha): 川崎 英也 関西大学, 化学生命工学部, 教授 (50322285)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 刺激応答性ゲル / 動的架橋 / 生体分子複合体 / DDS / 細胞制御 / センサーチップ / 分子認識 / 表面パターン

Outline of Final Research Achievements

In this study, dynamic gels were designed using biomolecular complexes and photo-dimerization as dynamic cross-links, and spatiotemporally controllable medical systems were developed using their gels. Dynamic gels with model drugs as dynamic cross-links regulated the drug release by the conformational change of the gel networks. Dynamic gels with molecular recognition sites were formed on gold sensor chips, enabling us to detect a target biomolecule sensitively and selectively. Biomolecule- and photo-responsive dynamic gels were strategically designed as smart scaffolds for regulating cell behavior.

Free Research Field

機能性高分子