2017 Fiscal Year Final Research Report
Novel Gold nanocluster-based Photosensitizers for Antimicrobial Photodynamic Therapy
| Project/Area Number |
15H03520
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Nanostructural chemistry
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| Research Institution | Kansai University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
宮治 裕史 北海道大学, 大学病院, 講師 (50372256)
大坂 一生 北陸先端科学技術大学院大学, ナノマテリアルテクノロジーセンター, 講師 (90550244)
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| Co-Investigator(Renkei-kenkyūsha) |
TAMURA Hiroshi 関西大学, 化学生命工学部, 教授 (20163694)
FURUIKE Tetsuya 関西大学, 化学生命工学部, 教授 (10360942)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 金ナノクラスター / 光増感剤 / PDT |
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| Outline of Final Research Achievements |
In this study, we have devoted to the exploration of potential diagnostic applications of water-soluble gold nanoclusters (Au NCs) with ultra-small sizes (< 2 nm). One of the therapeutic applications is the photosensitized generation of reactive oxygen species using Au NCs as a photosensitizer for photodynamic therapy (PDT). We have reported Au NC photosensitizers and the effects of their size and type of surface ligands on singlet oxygen (1O2) generation. The photo-excited Au NC undergoes intersystem crossing (ISC) from its lowest singlet excited state (S1) to the lowest triplet excited state (T1). Subsequently, the transfer of energy from the T1 state of the Au NC to the ground-state oxygen (3O2) generates 1O2, which causes oxidative damage of targets. the photosensitizers based on the Au based photosensitizers were successfully used for antimicrobial-PDT (a-PDT) against bacteria.
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| Free Research Field |
コロイド界面化学 材料化学
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