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2017 Fiscal Year Final Research Report

Development of New Nitrogen-based Ligands for Asymmetric Reactions with Highly Active Catalysts

Research Project

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Project/Area Number 15H03808
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Synthetic chemistry
Research InstitutionNagoya Industrial Science Research Institute (2016-2017)
Nagoya University (2015)

Principal Investigator

NISHIYAMA HISAO  公益財団法人名古屋産業科学研究所, 研究部, 研究員 (40135421)

Co-Investigator(Kenkyū-buntansha) 伊藤 淳一  名古屋大学, 工学研究科, 講師 (20402480)
Project Period (FY) 2015-04-01 – 2018-03-31
Keywords有機合成 / 不斉合成 / 触媒 / 有機金属化学 / 光学活性化合物
Outline of Final Research Achievements

In organic synthesis, it is important to develop new catalytic reaction providing useful optically active compounds. We have developed new nitrogen-based multidentate ligands for asymmetric catalysis. As N,C,N-type or N,N,O-type ligands, bis(oxazolinyl)phenyl or binaphthol-phenanthroline derivatives were examined to show high stereoselectivity and enantioselectivity for asymmetric conjugate silylation of substituted cyclohexadienones, conjugate addition and susequent alkylation, α-oxidation of oxindole skeleton etc., in the combination with a variety of metals. Plausible catalytic cycles including intermediate or transition state were examined by theoretical calculation to give the corresponding structures for asymmetric conjugate hydrosilylation.

Free Research Field

有機合成化学

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Published: 2019-03-29  

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