Development and application of advanced non-invasive imaging system for mice

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H04281
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Laboratory animal science
• Research Institution: University of Tsukuba
• Principal Investigator: Mira Yoshihiro 筑波大学, 医学医療系, 講師 (70263845)
• Co-Investigator(Kenkyū-buntansha): 松田 達志 関西医科大学, 医学部, 准教授 (00286444) ; 依馬 正次 滋賀医科大学, 動物生命科学研究センター, 教授 (60359578)
• Co-Investigator(Renkei-kenkyūsha): TAKAHASHI SATORU 筑波大学, 医学医療系, 教授 (50271896) ; OMIYA YOSHIHIRO 産業技術総合研究所, バイオメディカル研究部門, 部門長 (20223951) ; ISHIHARA MIYA 防衛医科大学, 医学教育部, 教授 (30505342)
• Research Collaborator: KIJIMA JUNKO 筑波大学, 医学医療系, 技術職員 (30517793)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 蛍光 / 非侵襲 / モデルマウス

Outline of Final Research Achievements

By developing degradation-regulated NIR fluorescent probe, we have realized high time resolution non-invasive imaging with living model mice. We have also developed fluorescent-bioluminescent dual imaging method. Furthermore, we applied established model mice. In future, these techniques would be very powerful approach for analysis of diseases and drug discovery.

Free Research Field

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