Identification and analysis of new androgen responsive regulatory genes for development and cancer.

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H04300
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Tumor biology
• Research Institution: Wakayama Medical University
• Principal Investigator: Yamada Gen 和歌山県立医科大学, 先端医学研究所, 教授 (80174712)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: アンドロゲン / 男性ホルモン / bZipファミリー / 癌関連繊維芽細胞 / MafB / 生殖器間葉細胞 / 外生殖器 / 前立腺

Outline of Final Research Achievements

The current study suggests that the Mafb 3' untranslated region (UTR) is an essential region for its regulation by androgen. We identified 2 functional androgen response elements (AREs) in Mafb 3UTR.
Androgen receptor is bound to such AREs in 3UTR during urethral masculinization. By using such identified UTR-enhancer, we revealed new candidate upstream gene for MafB regulation. Our ongoing study suggests such new transcription factor-AR interaction is essential for regulating MafB enhancer. CAF cells have been also suggested as playing essential role for prostate cancer. The current study gives insight for the regulation of bZip family gene function not only in embryonic mesenchyme cells but also for cancer associated fibroblast (CAF) cells.

Free Research Field

発生生殖医学