2017 Fiscal Year Final Research Report
Integrated genomic and epigenomic analyses to understand the molecular bases for defects in spermatogenesis in humans
| Project/Area Number |
15H04320
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical genome science
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
飯島 将司 金沢大学, 附属病院, 助教 (70749168)
並木 幹夫 金沢大学, 医学系, 特任教授 (70155985)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 男性不妊症 / ゲノム / エピゲノム |
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| Outline of Final Research Achievements |
Integrated genomic and epigenomic analyses including whole-exome sequencing analysis in Japanese patients with idiopathic nonobstructive azoospermia and testicular epigenomic analysis helped us identify candidate “hot spot” genes that harbored various types of mutations (such as genetic and epigenetic mutations). In a two-staged genome-wide association study of sperm motility in Japanese males, furthermore, a single nucleotide polymorphism rs3791686 in ERBB4 on chromosome 2q34 was identified as a novel locus for sperm motility.
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| Free Research Field |
ゲノム医科学
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