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2017 Fiscal Year Final Research Report

Molecular mechanism of force-sensing system and gene expression.

Research Project

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Project/Area Number 15H04327
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Molecular biology
Research InstitutionTohoku University

Principal Investigator

Ogura Toshihiko  東北大学, 加齢医学研究所, 教授 (60273851)

Project Period (FY) 2015-04-01 – 2018-03-31
Keywords転写 / 遺伝子発現 / 力刺激
Outline of Final Research Achievements

We have found that force-sensitive transcriptional co-activator MKL2 shuttles from cytoplasm into nucleus in very rapid response to shear stress, which completes within 10 minutes. We also found that this response is mediated by purinergic receptor activation and subsequent Ca signaling. To explore further the roles played by MKL2, we successfully made Mkl2 KO mice, which shows interesting phenotypes in circulatory system, such as heart and vasculatures. These phenotypes can be explained by a loss of response to mechanical stress in circulation. In addition, we found other unexpected interesting phenotypes in eyes and energy metabolism. We are preparing a manuscript, in which all data found in this project will be included.

Free Research Field

分子生物学

URL: 

Published: 2019-03-29  

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