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2017 Fiscal Year Final Research Report

Trial for determining the structure of CXCR7

Research Project

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Project/Area Number 15H04338
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Structural biochemistry
Research InstitutionKyoto University

Principal Investigator

Shimamura Tatsuro  京都大学, 医学研究科, 特定講師 (90391979)

Co-Investigator(Renkei-kenkyūsha) SUGA Hiroaki  東京大学, 大学院理学研究科, 教授 (00361668)
YAMANAKA Yasuaki  京都大学, 大学院医学研究科, 研究員 (10724049)
NOMURA Norimichi  京都大学, 大学院医学研究科, 助教 (10314246)
FUJIWARA Takaaki  京都大学, 大学院医学研究科, 研究員 (70712751)
Research Collaborator IM Dohyun  
Project Period (FY) 2015-04-01 – 2018-03-31
Keywords結晶構造解析 / Gタンパク質共役型受容体
Outline of Final Research Achievements

Chemokine receptor CXCR7 is a member of G protein coupled receptors (GPCR) and a potential drug target. CXCR7 is highly expressed in cancer cells and mediates tumor metastasis. Uniquely, CXCR7 does not couple to G protein but to beta-arrestin. The aim of this project is to determine the 3D structure of CXCR7. Currently, we have not succeeded to obtain crystals of CXCR7.

Free Research Field

構造生物学

URL: 

Published: 2019-03-29  

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