2017 Fiscal Year Final Research Report
Nuclear-specific arginine methylation of glycolytic enzymes regulates energy metabolism
| Project/Area Number |
15H04355
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 解糖系 / メチル化 / PRMT1 / 核移行 |
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| Outline of Final Research Achievements |
In cancer cells, the expression of glycolytic enzymes is regulated by stress-responsive transcriptional factors (e.g., HIF-Ia and c-Myc). Recent studies demonstrated that post-translational modifications of metabolic enzymes also regulate metabolic reprogramming. Our previous study showed that arginine methylation of glycolytic enzymes is spatial regulated in the nucleus. In this study, we clarified the mechanism of nuclear-specific arginine methylation of enzymes. Furthermore, we found that auto-methylation of PRMT1, which is a responsible methyltransferase for glycolytic enzymes influenced the nuclear translocation of PRMT1, resulted in nuclear-specific methylation of glycolytic enzymes.
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| Free Research Field |
代謝生化学
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