Mechanistic insight into how the autophagosomes form and searching for the drug regulating autophagy

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H04371
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cell biology
• Research Institution: Osaka University
• Principal Investigator: Hamasaki Maho 大阪大学, 生命機能研究科, 准教授 (30455216)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: オートファジー / 小胞体 / ミトコンドリア / 薬剤スクリーニング

Outline of Final Research Achievements

Autophagy, found by Dr. Ohsumi who won the 2016 Nobel Prize in Physiology or Medicine, is a cellular degradation system that can be induced by stress such as starvation. When cells are starved, part of cytosol and organelles are degraded and recycles to survive by forming organelles called "autophagosomes". Autophagosomes have a diameter of 1um and do not always exist in the cell, they forms when degradation is required. It has been over 20 years since autophagy related genes were identified yet how the autophagosomes are formed is unclear. Aim of this research is to characterize how the autohpagosome forms in detail.

Free Research Field

細胞生物