2017 Fiscal Year Final Research Report
Molecular mechanism underlying Strip-Hippo pathway regulates neural synapse formation
| Project/Area Number |
15H04375
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Developmental biology
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| Research Institution | Hiroshima University (2016-2017)
The University of Tokyo (2015) |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 神経発生 / シナプス / Hippo / ショウジョウバエ |
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| Outline of Final Research Achievements |
In this study, we tried to reveal the molecular mechanism underlying hippo pathway regulates neural function. By using Drosophila genetic screen, we identified the evolutionarily conserved amino acid transporter, HiAT (Hippo-interacting Amino acid Transporter) as a regulator of hippo pathway in neuronal synapse formation. Furthermore, we found that HiAT and hippo kinase can affect animal locomotor activity.
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| Free Research Field |
発生生物学
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