Studies of brain mechanisms underlying the maintenance of motivation for action resilient to fatigue load and their regulation by food

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H04500
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Food science
• Research Institution: Kyoto University
• Principal Investigator: Inoue Kazuo 京都大学, 農学研究科, 准教授 (80213148)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 疲労 / 脳内自己刺激 / 脳報酬系 / ストレス / 運動

Outline of Final Research Achievements

The determination of fatigue with intra-cranial self stimulation (ICSS) was studied in rats. Rate-frequency, fixed ratio and progressive ratio protocol were evaluated. All protocols detected the decrease in motive for acquiring reward stimulus after exercise load with treadmill running, however, only the RF protocols revealed the reduced motivation after emotional stress. The dopaminergic projection to nucleus accumbens was demonstrated to be related to the formation and maintenance of exercise will. The administration of caffeine caused the enhancement of continuing motivation for running in rats. Exercise training increased endurance capacity. After successful exercise training, it was determined by rate frequency protocol of ICSS that rats showed the lesser extent of fatigue to the same intensity of exercise load compared with those of non-trained rats.

Free Research Field

栄養化学