Study of long noncoding RNAs in immune response

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H04642
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biological pharmacy
• Research Institution: The University of Tokyo
• Principal Investigator: Akimitsu Nobuyoshi 東京大学, アイソトープ総合センター, 教授 (40294962)
• Co-Investigator(Kenkyū-buntansha): 高屋 明子 千葉大学, 大学院薬学研究院, 准教授 (80334217) ; 神吉 康晴 東京大学, アイソトープ総合センター, 助教 (00534869)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: RNA / 感染 / 自然免疫

Outline of Final Research Achievements

We found that nuclear RNA degradation pathway is dysregulated in response to Salmonella infection, causing the upregulation of nuclear long noncoding RNAs that are unstable in human nucleus of naïve cells. The nuclear long noncoding RNAs induced upon Salmonella infection are involved in the regulation of immune-related genes such as interferons. In addition, we showed that MTR4, an important component of nuclear RNA degradation pathways, are diminished after Salmonella infection. Our study clearly show the importance of nuclear RNA degradation pathway in immune response.

Free Research Field

分子生物学