Development of Novel Drug Discovery Technologies for Target Proteins with Elusive Molecular Basis

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H04654
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Drug development chemistry
• Research Institution: Kyoto University
• Principal Investigator: Fujii Nobutaka 京都大学, 薬学研究科, 名誉教授 (60109014)
• Co-Investigator(Kenkyū-buntansha): 大野 浩章 京都大学, 薬学研究科, 教授 (30322192)
• Co-Investigator(Renkei-kenkyūsha): NAKANISHI Isao 近畿大学, 薬学部, 教授 (10362576) ; OISHI Shinya 京都大学, 大学院薬学研究科, 准教授 (80381739)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: ペプチド / 複素環 / GPCR / ケモカイン / 創薬テンプレート / 合理的分子設計 / キナーゼ

Outline of Final Research Achievements

Through the structure-activity relationship study of cyclic pentapeptide CXCR7 ligands, a number of potent and highly selective ligands were identified. The binding modes and structural requirements of some representative ligands were revealed by molecular modeling studies. Efficient synthetic approaches for alkaloid scaffolds were developed, which can be applicable to medicinal chemistry studies. Furthermore, several inhibitory molecules with unique biological and/or functional properties were identified against sphingosine kinases, CK2 kinases and NK3 receptor via the structure-activity relationship studies.

Free Research Field

創薬化学