Prevention of a virus propagation based on cellular factors controlling HIV infection

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H04659
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Environmental and hygienic pharmacy
• Research Institution: Kumamoto University
• Principal Investigator: Shogo Misumi 熊本大学, 大学院生命科学研究部(薬), 教授 (40264311)
• Co-Investigator(Kenkyū-buntansha): 高宗 暢暁 熊本大学, 熊本創生推進機構, 准教授 (60322749)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: HIV-1 / 宿主因子

Outline of Final Research Achievements

In this study, we showed that glycolysis enzymes GAPDH, Enolase, PKM 2 inhibit HIV-1 replication. In particular, GAPDH and PKM 2 inhibited HIV-1 replication by inhibiting packaging of tRNALys3, a reverse transcriptase primer, into viral particles. Moreover, we demonstrated that the uncoating process of HIV-1 is suppressed by FDA-approved Trametinib. These findings are useful for the development of a more effective anti-HIV strategy.

Free Research Field

生化学