Protective effects of Shati/Nat8l on the dysfunction induced by addictive drugs

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H04662
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Medical pharmacy
• Research Institution: University of Toyama
• Principal Investigator: Nitta Atsumi 富山大学, 大学院医学薬学研究部(薬学), 教授 (20275093)
• Co-Investigator(Kenkyū-buntansha): 宮本 嘉明 富山大学, 大学院医学薬学研究部(薬学), 准教授 (20449101) ; 宇野 恭介 富山大学, 大学院医学薬学研究部(薬学), 助教 (30608774)
• Co-Investigator(Renkei-kenkyūsha): MURAMATSU Shin-Ichi 自治医科大学, 教授 (10239543)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: Ｓｈａｔｉ／Ｎａｔ８ｌ / 危険ドラッグ / ＴＨＣ / メタンフェタミン / AAV / マウス

Outline of Final Research Achievements

“Kiken Drugs” are including two type of chemical compounds, cathinone and cannabinoid derivatives. Shati/Nat8l was originally isolated from the nucleus accumbens of mice as a methamphetamine-related molecule. Since then, Shati/Nat8l has been characterized as an N-acetyltransferase 8-like protein that catalyzes N-acetylaspartate (NAA) synthesis from aspartate and acetyl- co enzyme A. The pharmacological effects of methamphetamine were inhibited in Shati/Nat8l-onverexpressed mice, in locomotor activity test and conditioned prederence tests. Tetrahydrocannabinol (THC) did not occur the significant dependent effects, but induced anxiety-like behaviors. The anxiety-like behaviors were not depressed in the Shati/Nat8l-onverexpressed mice. These results suggest that Shati/Nat8l has inhibitory effects on the phthe one type of “Kiken Drugs” ,but does not another.

Free Research Field

神経精神薬理学、薬物治療学、医療薬学