2017 Fiscal Year Final Research Report
Clarification of molecular mechanisms of chronic allograft nephropathy focusing on adverse reaction of immunosuppressive drugs, and survey of noninvasive markers
| Project/Area Number |
15H04666
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Medical pharmacy
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
北田 秀久 九州大学, 大学病院, 助教 (10403958)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
YANO Takahisa 九州大学, 大学病院, 薬剤主任 (90532846)
|
|---|
| Research Collaborator |
KAJIWARA Moto
TAJIMA Soichiro
YAMAMOTO Nanae
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | 臨床薬学 / 免疫抑制薬 / 副作用 / 移植 / バイオマーカー / 安全性バイオマーカー / 非侵襲 |
|---|
| Outline of Final Research Achievements |
Chronic allograft nephropathy (CAN) after kidney transplantation results in dysfunction like chronic kidney disease with advanced fibrosis. In order to overcome CAN in kidney transplantation therapy, urinary biomarkers leading to fibrosis of transplanted kidney tissue were examined. By use of urine and blood samples from 73 patients after renal transplantation, and analyzed the relationship between urinary biomarker candidate protein and clinical course and analyzed with tissue damage mainly including acute rejection and tubularitis found after 3 months postoperative course were shown. As a result, the urinary NGAL, MCP-1 and LC3 were shown as an useful index for early prediction of CNI-induced renal impairment after renal transplantation.
|
| Free Research Field |
臨床薬理学
|
