2017 Fiscal Year Final Research Report
Development of a method for simultaneous recordings of single channel dynamics and currents
| Project/Area Number |
15H04675
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
General physiology
|
|---|
| Research Institution | University of Fukui |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
岩本 真幸 福井大学, 学術研究院医学系部門, 助教 (40452122)
平井 義和 京都大学, 工学(系)研究科(研究院), 研究員 (40452271)
|
|---|
| Research Collaborator |
Tabata Osamu 京都大学, 大学院・工学系研究科, 教授 (20288624)
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | 1分子計測 / 蛋白質 / X線回折 / イオンチャネル |
|---|
| Outline of Final Research Achievements |
Ion channel proteins are ion permeation pathway across cell membranes, whose functions are recorded with single-channel current recording method. The structure of KcsA potassium channel was first resolved at atomic resolutions among the ion channel proteins. We previously succeeded in recording conformational changes of the KcsA channel with the diffracted x-ray tracking method in a single-molecule level. In this study we tried to fabricate a new recording chamber and probes aiming to current-dynamics simultaneous recordings for the ion channel proteins.
|
| Free Research Field |
生理学 生物物理学
|
