2017 Fiscal Year Final Research Report
Study on TRIC channel and MG56
| Project/Area Number |
15H04676
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
General physiology
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | TRICチャネル / ミツグミン56 |
|---|
| Outline of Final Research Achievements |
The muscle sarcoplasmic reticulum (SR) is a unique organelle specialized for Ca2+ handling, and we have identified TRIC channels and MG56 as SR component proteins. This research project has been designed to examine the physiological roles of the SR components, and yielded several novel results partly described below. We identified the pathological mechanism underlying TRIC-B-mutated osteogenesis imperfecta; the loss of TRIC-B impairs bone matrix synthesis due to compromised Ca2+ store functions in osteoblasts. On the other hand, MG56-knockout mice develop morphological abnormalities in the muscle SR and die during lactation stages due to suckling failure.
|
| Free Research Field |
生化学
|
