Identification of aldosterone-producing cells: Explore the novel mechanism of the hypertension-induced organ damages

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H04711
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Human pathology
• Research Institution: Tohoku University
• Principal Investigator: SASANO Hironobu 東北大学, 医学系研究科, 教授 (50187142)
• Co-Investigator(Renkei-kenkyūsha): NAKAMURA Yasuhiro 東北医科薬科大学, 医学部, 教授 (80396499) ; ARAI Yoichi 東北大学, 大学院医学系研究科, 教授 (50193058) ; SATOH Fumitoshi 東北大学, 医学系研究科, 特任教授 (70343051) ; MORIMOTO Ryo 東北大学, 大学病院, 講師 (30547394)
• Research Collaborator: Rainey William E ; Gomez-Sanchez Celso E ; ONO Katsuhiko ; ISE Kazue ; YAMAZAKI Yuto
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: アルドステロン / CYP11B2 / 高血圧 / 原発性アルドステロン症 / 免疫組織化学 / KCNJ5 / 副腎皮質球状層

Outline of Final Research Achievements

In this present study, the novel histopathological classification of cross-sectional image negative non-neoplastic hyperaldosteronism has been proposed based on the distribution of aldosterone-producing cells. Furthermore, this is the first study to demonstrate that aldosterone-producing cell clusters (APC) frequently harbors aldosterone-driver gene somatic mutation and accumulate with age.

Free Research Field

副腎皮質細胞におけるステロイドホルモン合成の機能と形態との関係性