2017 Fiscal Year Final Research Report
Role of NKG2D ligands in pathologic conditions
| Project/Area Number |
15H04716
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
大塚 紀幸 北海道大学, 医学研究院, 助教 (00447046)
宮武 由甲子 北海道大学, 医学(系)研究科(研究院), その他 (10421984)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | NKG2Dリガンド / MHC / NK細胞 / 褥瘡 / 胎盤形成 |
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| Outline of Final Research Achievements |
NKG2D ligands are a group of major histocompatibility complex class I-like molecules whose expression is induced by cellular stresses such as transformation and viral infections. They act as a danger signal alerting the immune system to the presence of abnormal cells. In this project, we analyzed the role of NKG2D ligands in pressure ulcers and placental development using mouse models. We also conducted molecular evolutionary analysis of the NKG2D ligand gene family in mammals.
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| Free Research Field |
病理学
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