2017 Fiscal Year Final Research Report
Challenge to the standardization and harmonization of immunoassay results, toward the scientific laboratory medicine
| Project/Area Number |
15H04760
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 臨床検査 / 標準化 / ハーモナイゼーション / コミュータビリティ / APTM / 可溶性IL-2受容体 / PIVKA-Ⅱ / プロカルシトニン |
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| Outline of Final Research Achievements |
It is required that clinical laboratory measurement results be comparable between laboratories and methods for different methods. This has been achieved only for a much smaller number of analytes especially in immunoassay. Although there are any reagents and analyzers for measurement of soluble IL-2 receptor and PIVKA-II, adequate correlations among the measurement methods and not so big differences between the average of the methods and each method were observed by use of patients’ sera. Immunochromatography is widely used to analyze procalcitonin levels due to its simple and easy procedure. Therefore, the correlations of the measurement results analyzed by between immunochromatography and highly sensitive immunoassay were investigated to be revealed acceptable.
In conclusion, for harmonization of laboratory results, all procedure trimmed mean (APTM) is recommended, however, cooperation of industry, government and academia is much more important.
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| Free Research Field |
臨床検査医学
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