Crosstalk of inflammatory responses and microRNA expression induced by particulate matters and application for risk assessment

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H04784
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hygiene and public health
• Research Institution: Mie University
• Principal Investigator: Hiraku Yusuke 三重大学, 医学系研究科, 講師 (30324510)
• Co-Investigator(Renkei-kenkyūsha): OMAE KAZUYUKI 慶應義塾大学, 名誉教授 (60118924) ; TANAKA AKIYO 九州大学, 医学研究院, 講師 (10136484)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 粒子状物質 / 炎症 / マイクロRNA / 石綿 / 発がん / リスク評価

Outline of Final Research Achievements

Particlate matters are accumulated in the respiratory systems by inhalation exposure and induce chronic inflammation, leading to carcinogenesis and fibrosis. To clarify the mechanism of diseases caused by these materials, we examined the association of inflammatory responses and the expression of microRNA (miRNA). In lung tissues of indium-exposed rats, miR-21 expression was predicted to target prostaglandin dehydrogenase, leading to augmentation of inflammatory responses. In the sera of indium-exposed rats, several inflammatory cytokines were upregulated and supposed to involve downregulation of miRNAs in lung tissues. These results raise a possibility that these miRNAs and related inflammatory molecules can be potential biomarkers to evaluate the risk of individuals exposed to harmful particulate matters.

Free Research Field

衛生学