2017 Fiscal Year Final Research Report
Investigation of pathological mechanism and therapeutic strategies of frailty based on AgingDomino theory
| Project/Area Number |
15H04800
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General internal medicine(including psychosomatic medicine)
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
小川 純人 東京大学, 医学部附属病院, 准教授 (20323579)
小島 太郎 東京大学, 医学部附属病院, 助教 (40401111)
石井 伸弥 東京大学, 医学部附属病院, 助教 (80710996)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | フレイル / 階層構造 / 老化 / 慢性炎症 / 大動脈瘤 |
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| Outline of Final Research Achievements |
Based on AgingDomino theory that indicates hierarchical relationship in the process of cell/tissue aging leading frailty, the hypothesis of this study was that unraveling this relationship could innovate the preventive and therapeutic strategies of frailty or aging-related diseases. Especially, in this study, we found vascular aging is an upstream trigger for aging of other frailty-related cell/tissue and mechanistically, found that expansion of inflammation causes this relationship. In detail, in normal aging or senescence accelerated mice, vascular inflammation promoted aging-dependent changes or dysfunction of skeletal muscle and brain tissue. Also, enhancement of circulating inflammatory cytokines (e.g. IL-6) by vascular inflammation leads to exaggerated inflammatory response in downstream tissue through perturbation of systemic inflammatory regulation.
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| Free Research Field |
老年医学
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