2017 Fiscal Year Final Research Report
Exploring the novel compounds targeting dysregulated autophagy-mediated cardiac dysfunction
| Project/Area Number |
15H04817
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
ISOBE Mitsuaki 東京医科歯科大学, 大学院医歯学総合研究科, 非常勤講師 (80176263)
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| Co-Investigator(Kenkyū-buntansha) |
前嶋 康浩 東京医科歯科大学, 医学部附属病院, 助教 (40401393)
秦野 雄 東京医科歯科大学, 医学部附属病院, 助教 (00736407)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | オートファジー / 心不全 |
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| Outline of Final Research Achievements |
Based on our previous result that cardiac function is mediated through suppression of autophagy by phosphorylating Beclin1 by Mst1, we explored novel low molecular compounds which can competitively inhibit Beclin1-Bcl2/xL interaction that is enhanced by phosphorylation of Beclin1. As a result, we could identified such a compound. According to in vivo experiments, that compound could effectively alleviates cardiac disfunction in transverse aortic constriction mouse models.
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| Free Research Field |
循環器内科学
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